Serotonin, noradrenaline, dopamine metabolites in transcendental meditation-technique:

Bujatti, M; Riederer, P(1976): Journal of Neurotransmission Volume 39, Number 3 / September, 1976 257-267



  The highly significant increase of 5-HIAA (5-hydroxyindole-3-acetic acid) in Transcendental Meditation technique suggests systemic serotonin as „rest and fulfillment hormon“ of deactivation-relaxation.

Furthermore 5-HT (5-hydroxytryptamine, serotonin) is considered to to be the EC-cell (enterochromaffine-cell) hormone requested by Fujita and Kobayashi and its role for EEG synchronisation via area postrema chemo-receptor as anti arousal agent is being discussed.

The significant decrease of the catecholamine metabolite VMA (vanillic-mandelic acid) in meditators, that is associated with a reciprocal increase of 5-HIAA supports as a feedback necessity the „rest and fulfillment response“ versus „fight and flight“.

As the adreno medullary tissue serves for hormonal reinforcement of orthosympathetic activity, the Enterochromaffine Cell System (having taken the form of distinct organs in some species as octopus and discoglossus) is suggested to serve via serotonin for humoral reinforcement of parasympathetic activity in deep relaxation.

Online: SpringerLink

The results of this work have been partly contributed to the neuroscience meeting Sept. 4, 1975 at Courchevel and the MERU-Symposium Hamburg May 22, 1976.